Dr. Perry has four ongoing research projects that are unified by a common theme; the adaptation of fish to stressful or extreme environments. 1) The role of stress hormones in controlling cardio respiratory function and blood gas transport in fish during environmental disturbances. 2) The physiological and molecular nature of gill and renal transepithelial ion movements and their modulation during environmental and acid-base disturbances. 3) The molecular basis of hypoxic pre-conditioning in zebra fish and the ontogenetic effects of chronic environmental disturbances on cardio respiratory function. 4) The nature of oxygen and carbon dioxide sensing by chemoreceptors and its linkage to cardio respiratory control.

Selected publications:

  • Zimmer, A. M., Shir-Mohammadi, K., Kwong, R. W. M. and Perry, S. F. (2020). Reassessing the contribution of the Na+/H+ exchanger Nhe3b to Na+ uptake in zebrafish (Danio rerio) using CRISPR/Cas9 gene editing. J. Exp. Biol. 223, jeb215111.
  • Yew, H. M., Zimmer, A. M. and Perry, S. F. (2020). Assessing intracellular pH regulation in H+-ATPase-rich ionocytes in zebrafish larvae using in vivo ratiometric imaging. The Journal of Experimental Biology 223, jeb212928.
  • Mandic, M., Best, C. and Perry, S. F. (2020). Loss of hypoxia inducible factor 1a affects hypoxia tolerance in larval and adult zebrafish (Danio rerio). Proc. Roy. Soc. B 287, 20200798.
  • Hughes, M. C., Zimmer, A. M. and Perry, S. F. (2019). Role of internal convection in respiratory gas transfer and aerobic metabolism in larval zebrafish (Danio rerio). American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 316, R255-R264.
  • Gilmour, K. M. and Perry, S. F. (2018). Conflict and Compromise: Using Reversible Remodeling to Manage Competing Physiological Demands at the Fish Gill. Physiology 33, 412-422.